Direct Flights from Detroit to St Louis
St Louis · Missouri
Nonstop service from DTW to STL on Delta, Southwest. Here's the schedule at a glance — plus what to do once you land.
How rare is this nonstop?
50 cities have a nonstop to St Louis, Detroit among them.
How long to go to St Louis for, from Detroit
1h 25m in the air, 439 miles: short enough that a single night in St Louis is worth it, and a day trip is not absurd.
With roughly 5 departures a day, you are not tied to one flight: if a meeting overruns or the weather turns, there is another one behind it.
About St Louis
The Gateway City of St. Louis is the epitome of the modern Midwestern metropolis. Missouri's second-largest city is vibrant but laid-back, populous but navigable, historic but still relevant. The city's planners have created an aesthetically beautiful city, with plenty of green space amidst buildings both old and new, framed by the majestic Mississippi and Missouri rivers. And capping it all is the world's tallest man-made monument, the beautiful and iconic Gateway Arch.
Summary from Wikivoyage (CC BY-SA).
Top things to do in St Louis
- The Cahokia Mounds is the site of a Native American city directly across the Mississippi River from present-day St. Louis. The state archaeology park lies in south-western Illinois between East St.
- The Gateway Arch is a 630-foot-tall (192 m) monument in St. Louis, Missouri, United States.
- The Missouri Botanical Garden is a botanical garden located at 4344 Shaw Boulevard in St. Louis, Missouri. It is also known informally as Shaw's Garden for founder and philanthropist Henry Shaw.
- Gateway Arch National Park is a national park of the United States located in St. Louis, Missouri, near the starting point of the Lewis and Clark Expedition.
- The Saint Louis Art Museum (SLAM) is an art museum located in St. Louis, Missouri, United States.
- Monks Mound is the largest Pre-Columbian earthwork in the Americas and the largest pyramid north of Mesoamerica. The beginning of its construction dates from 900 to 955 CE.
- The Cathedral Basilica of Saint Louis, also known as the Saint Louis Cathedral or the New Cathedral, is a Catholic cathedral in the Central West End neighborhood of St. Louis, Missouri.
- The Saint Louis Zoo, officially known as the Saint Louis Zoological Park, is a zoo in Forest Park in St. Louis, Missouri. It is recognized as a leading zoo in animal management, research, conservation, and education.
- The Piasa or Piasa Bird is a creature from Native American mythology depicted in one of two murals painted by Native Americans on cliffsides above the Mississippi River.
- Six Flags St. Louis is an amusement park in Eureka, Missouri, a suburb of St. Louis. Founded by Six Flags, the park was purchased in 2026 by EPR Properties, which hired Enchanted Parks to operate it.
- Forest Park is a public park in western St. Louis, Missouri. It is a prominent civic center and covers 1,326 acres (5.37 km2).
- The Mildred Lane Kemper Art Museum is an art museum located on the campus of Washington University in St. Louis, within the university's Sam Fox School of Design & Visual Arts. Founded in 1881 as the St.
Attraction descriptions from Wikipedia (CC BY-SA); place data from Wikidata (CC0).
St Louis weather, compared with Detroit
7° warmer than Detroit on average across the year, on daytime highs:
- January
- St Louis 41°F · Detroit 33°F · 8° warmer
- April
- St Louis 68°F · Detroit 59°F · 9° warmer
- July
- St Louis 90°F · Detroit 84°F · 6° warmer
- October
- St Louis 69°F · Detroit 62°F · 7° warmer
January bottoms out near 41°F — a real coat, not a layer.
Average daily highs, 1991–2020 station normals from Meteostat (CC BY 4.0), measured at the nearest weather station to each city.
Planning a trip to St Louis
- Best time to visit
- The best time to visit St Louis is April–May and September–October, when daytime highs are a comfortable 68–81°F.
- How long to stay
- St Louis rewards a longer visit — a full week lets you explore its many sights, from Cahokia, Gateway Arch, and Missouri Botanical Garden and beyond.
Frequently asked questions
- Is there a direct flight from Detroit to St Louis?
- Yes — you can fly nonstop from Detroit (DTW) to St Louis (STL) on Delta, Southwest.
- Which airlines fly nonstop from Detroit to St Louis?
- Delta, Southwest fly nonstop between Detroit (DTW) and St Louis (STL).
- How many nonstop flights are there from Detroit to St Louis?
- There are about 5 nonstop departures per day (roughly 35 per week) from Detroit to St Louis.
- How far is St Louis from Detroit?
- St Louis is about 439 miles from Detroit by air.
- What is there to do in St Louis?
- Popular things to do include Cahokia, Gateway Arch, Missouri Botanical Garden, Gateway Arch National Park, and more.
More nonstop destinations from Detroit near St Louis
Airports near Detroit
The closest other departure airports to Detroit — each opens up more nonstop destinations.