Is there a direct flight from Dallas to Columbus, Mississippi?

Yes — you can fly nonstop from Dallas (DFW) to Columbus, Mississippi (GTR) on American.

Which airlines fly nonstop from Dallas to Columbus, Mississippi?

American flies nonstop between Dallas (DFW) and Columbus, Mississippi (GTR).

There is about 1 nonstop departure per day (roughly 7 per week) from Dallas to Columbus, Mississippi.

Columbus, Mississippi is about 490 miles from Dallas by air.

Popular things to do include Plymouth, Mississippi, Bynum Mound and Village Site, Lake Lowndes State Park, Legion State Park, and more.

Nonstop service from DFW to GTR on American. Here's the schedule at a glance — plus what to do once you land.

Airlines

American

Nonstop flights

~1/day

Distance

490 mi

Flight time

~1h 30mgate to gate

Elevation

264 ft343 ft lower than your departure

Days operated

Daily (all week)

This is a rare nonstop: only 2 cities fly direct to Columbus, Mississippi, and Dallas is one of them. From anywhere else you'd be connecting.

1h 30m in the air, 490 miles — a Friday-evening departure still leaves you most of the evening in Columbus, Mississippi. Two nights works.

Columbus is a city in eastern Mississippi, near the border with Alabama.

Summary from Wikivoyage (CC BY-SA).

Plymouth, Mississippi
Plymouth was an early settlement in Mississippi in present-day Lowndes County. Plymouth was located on the west bank of the Tombigbee River at the mouth of Tibbee Creek.
Bynum Mound and Village Site
The Bynum Mound and Village Site (22CS501) is a Middle Woodland period archaeological site located near Houston in Chickasaw County, Mississippi.
Lake Lowndes State Park
Lake Lowndes State Park is a public recreation area in the U.S. state of Mississippi located off Mississippi Highway 69, eight miles (13 km) southeast of Columbus, Mississippi.
Legion State Park
Legion State Park is public recreation area located on the north edge of the city of Louisville, Mississippi, and adjacent to Tombigbee National Forest.
Cotton Gin Port, Mississippi
Cotton Gin Port is a ghost town in Monroe County, Mississippi, United States.
Dancing Rabbit Creek Treaty Site
The Dancing Rabbit Creek Treaty Site is a historic Choctaw Native American gathering place in rural Noxubee County, Mississippi.

Attraction descriptions from Wikipedia (CC BY-SA); place data from Wikidata (CC0).

Within 3° of Dallas on the annual average, so pack much as you would at home — but the two cities do not track each other month to month:

Daily highs averaged from Meteostat station records (CC BY 4.0), measured at each city's airport.

Best time to visit: The best time to visit Columbus, Mississippi is February–April and October–November, when daytime highs are a comfortable 60–76°F.
How long to stay: Three or four days is enough to take in Columbus, Mississippi's highlights, from Plymouth, Mississippi, Bynum Mound and Village Site, and Lake Lowndes State Park and more.

Is there a direct flight from Dallas to Columbus, Mississippi?: Yes — you can fly nonstop from Dallas (DFW) to Columbus, Mississippi (GTR) on American.
Which airlines fly nonstop from Dallas to Columbus, Mississippi?: American flies nonstop between Dallas (DFW) and Columbus, Mississippi (GTR).
How many nonstop flights are there from Dallas to Columbus, Mississippi?: There is about 1 nonstop departure per day (roughly 7 per week) from Dallas to Columbus, Mississippi.
How far is Columbus, Mississippi from Dallas?: Columbus, Mississippi is about 490 miles from Dallas by air.
What is there to do in Columbus, Mississippi?: Popular things to do include Plymouth, Mississippi, Bynum Mound and Village Site, Lake Lowndes State Park, Legion State Park, and more.

The closest other departure airports to Dallas — each opens up more nonstop destinations.