Direct Flights from Charlotte to St Louis
St Louis · Missouri
Nonstop service from CLT to STL on American, Southwest. Here's the schedule at a glance — plus what to do once you land.
How rare is this nonstop?
50 cities have a nonstop to St Louis, Charlotte among them.
How long to go to St Louis for, from Charlotte
1h 40m in the air, 574 miles — a Friday-evening departure still leaves you most of the evening in St Louis. Two nights works.
With roughly 5 departures a day, you are not tied to one flight: if a meeting overruns or the weather turns, there is another one behind it.
About St Louis
The Gateway City of St. Louis is the epitome of the modern Midwestern metropolis. Missouri's second-largest city is vibrant but laid-back, populous but navigable, historic but still relevant. The city's planners have created an aesthetically beautiful city, with plenty of green space amidst buildings both old and new, framed by the majestic Mississippi and Missouri rivers. And capping it all is the world's tallest man-made monument, the beautiful and iconic Gateway Arch.
Summary from Wikivoyage (CC BY-SA).
Top things to do in St Louis
- The Cahokia Mounds is the site of a Native American city directly across the Mississippi River from present-day St. Louis. The state archaeology park lies in south-western Illinois between East St.
- The Gateway Arch is a 630-foot-tall (192 m) monument in St. Louis, Missouri, United States.
- The Missouri Botanical Garden is a botanical garden located at 4344 Shaw Boulevard in St. Louis, Missouri. It is also known informally as Shaw's Garden for founder and philanthropist Henry Shaw.
- Gateway Arch National Park is a national park of the United States located in St. Louis, Missouri, near the starting point of the Lewis and Clark Expedition.
- The Saint Louis Art Museum (SLAM) is an art museum located in St. Louis, Missouri, United States.
- Monks Mound is the largest Pre-Columbian earthwork in the Americas and the largest pyramid north of Mesoamerica. The beginning of its construction dates from 900 to 955 CE.
- The Cathedral Basilica of Saint Louis, also known as the Saint Louis Cathedral or the New Cathedral, is a Catholic cathedral in the Central West End neighborhood of St. Louis, Missouri.
- The Saint Louis Zoo, officially known as the Saint Louis Zoological Park, is a zoo in Forest Park in St. Louis, Missouri. It is recognized as a leading zoo in animal management, research, conservation, and education.
- The Piasa or Piasa Bird is a creature from Native American mythology depicted in one of two murals painted by Native Americans on cliffsides above the Mississippi River.
- Six Flags St. Louis is an amusement park in Eureka, Missouri, a suburb of St. Louis. Founded by Six Flags, the park was purchased in 2026 by EPR Properties, which hired Enchanted Parks to operate it.
- Forest Park is a public park in western St. Louis, Missouri. It is a prominent civic center and covers 1,326 acres (5.37 km2).
- The Mildred Lane Kemper Art Museum is an art museum located on the campus of Washington University in St. Louis, within the university's Sam Fox School of Design & Visual Arts. Founded in 1881 as the St.
Attraction descriptions from Wikipedia (CC BY-SA); place data from Wikidata (CC0).
St Louis weather, compared with Charlotte
5° cooler than Charlotte on average across the year, on daytime highs:
- January
- St Louis 41°F · Charlotte 52°F · 12° colder
- April
- St Louis 68°F · Charlotte 73°F · 5° colder
- July
- St Louis 90°F · Charlotte 90°F · much the same
- October
- St Louis 69°F · Charlotte 73°F · 4° colder
January bottoms out near 41°F — a real coat, not a layer.
Average daily highs, 1991–2020 station normals from Meteostat (CC BY 4.0), measured at the nearest weather station to each city.
Planning a trip to St Louis
- Best time to visit
- The best time to visit St Louis is April–May and September–October, when daytime highs are a comfortable 68–81°F.
- How long to stay
- St Louis rewards a longer visit — a full week lets you explore its many sights, from Cahokia, Gateway Arch, and Missouri Botanical Garden and beyond.
Frequently asked questions
- Is there a direct flight from Charlotte to St Louis?
- Yes — you can fly nonstop from Charlotte (CLT) to St Louis (STL) on American, Southwest.
- Which airlines fly nonstop from Charlotte to St Louis?
- American, Southwest fly nonstop between Charlotte (CLT) and St Louis (STL).
- How many nonstop flights are there from Charlotte to St Louis?
- There are about 5 nonstop departures per day (roughly 35 per week) from Charlotte to St Louis.
- How far is St Louis from Charlotte?
- St Louis is about 574 miles from Charlotte by air.
- What is there to do in St Louis?
- Popular things to do include Cahokia, Gateway Arch, Missouri Botanical Garden, Gateway Arch National Park, and more.
More nonstop destinations from Charlotte near St Louis
Airports near Charlotte
The closest other departure airports to Charlotte — each opens up more nonstop destinations.